InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akap12

Summary

InnateDB Protein

IDBP-131902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akap12

Protein Name

A kinase (PRKA) anchor protein (gravin) 12

Synonyms

AI317366; Srcs5; SSeCKS; Tsga12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035829

InnateDB Gene

IDBG-131898 (Akap12)

Protein Structure

UniProt Annotation

Function

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is predominantly found in the nervous system. Isoform 3 is testis specific. {ECO:0000269PubMed:11429284}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0030159	receptor signaling complex scaffold activity
GO:0051018	protein kinase A binding

Biological Process

GO:0006605	protein targeting
GO:0007165	signal transduction
GO:0010739	positive regulation of protein kinase A signaling
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0090036	regulation of protein kinase C signaling