InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Car2

Summary

InnateDB Protein

IDBP-132076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Car2

Protein Name

carbonic anhydrase 2

Synonyms

AI131712; Ca2; CAII; Car-2; Ltw-5; Lvtw-5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029078

InnateDB Gene

IDBG-132074 (Car2)

Protein Structure

UniProt Annotation

Function

Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. {ECO:0000269PubMed:20150244}.

Subcellular Localization

Cytoplasm. Cell membrane {ECO:0000250}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004089	carbonate dehydratase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001822	kidney development
GO:0002009	morphogenesis of an epithelium
GO:0006730	one-carbon metabolic process
GO:0006885	regulation of pH
GO:0009268	response to pH
GO:0010033	response to organic substance
GO:0010043	response to zinc ion
GO:0015670	carbon dioxide transport
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0032849	positive regulation of cellular pH reduction
GO:0038166	angiotensin-activated signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043627	response to estrogen
GO:0044070	regulation of anion transport
GO:0045672	positive regulation of osteoclast differentiation
GO:0045780	positive regulation of bone resorption
GO:0046903	secretion
GO:0048545	response to steroid hormone
GO:0051453	regulation of intracellular pH
GO:0071498	cellular response to fluid shear stress
GO:2001150	positive regulation of dipeptide transmembrane transport
GO:2001225	regulation of chloride transport

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0016323	basolateral plasma membrane
GO:0030424	axon
GO:0043209	myelin sheath
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome