InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Car2

Summary

InnateDB Gene

IDBG-132074.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Car2

Gene Name

carbonic anhydrase 2

Synonyms

AI131712; Ca2; CAII; Car-2; Ltw-5; Lvtw-5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027562

Encoded Proteins

IDBP-132076

carbonic anhydrase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104267:
CA2 is one of several (at least 7) isozymes of carbonic anhydrase. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:14886426-14900769

Strand

Forward strand

Band

Transcripts

ENSMUST00000029078

ENSMUSP00000029078

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004089	carbonate dehydratase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001822	kidney development
GO:0002009	morphogenesis of an epithelium
GO:0006730	one-carbon metabolic process
GO:0006885	regulation of pH
GO:0009268	response to pH
GO:0010033	response to organic substance
GO:0010043	response to zinc ion
GO:0015670	carbon dioxide transport
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0032849	positive regulation of cellular pH reduction
GO:0038166	angiotensin-activated signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043627	response to estrogen
GO:0044070	regulation of anion transport
GO:0045672	positive regulation of osteoclast differentiation
GO:0045780	positive regulation of bone resorption
GO:0046903	secretion
GO:0048545	response to steroid hormone
GO:0051453	regulation of intracellular pH
GO:0071498	cellular response to fluid shear stress
GO:2001150	positive regulation of dipeptide transmembrane transport
GO:2001225	regulation of chloride transport

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0016323	basolateral plasma membrane
GO:0030424	axon
GO:0043209	myelin sheath
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome