InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adi1

Summary

InnateDB Protein

IDBP-132100.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adi1

Protein Name

acireductone dioxygenase 1

Synonyms

AL024210; Fe-ARD; MTCBP-1; Ni-ARD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020957

InnateDB Gene

IDBG-132098 (Adi1)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. {ECO:0000255HAMAP-Rule:MF_03154}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03154}. Nucleus {ECO:0000255HAMAP-Rule:MF_03154}. Cell membrane {ECO:0000255HAMAP-Rule:MF_03154}; Peripheral membrane protein {ECO:0000255HAMAP-Rule:MF_03154}; Cytoplasmic side {ECO:0000255HAMAP-Rule:MF_03154}. Note=Localizes to the plasma membrane when complexed to MMP14. {ECO:0000255HAMAP- Rule:MF_03154}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:2144929

InterPro

IPR003313 AraC-type arabinose-binding/dimerisation domain
IPR004313 Acireductone dioxygenase ARD family
IPR011051 RmlC-like cupin domain
IPR013096 Cupin 2, conserved barrel

PFAM

PF02311
PF03079
PF07883

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99JT9

PhosphoSite