InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6ap2

Summary

InnateDB Protein

IDBP-132199.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6ap2

Protein Name

ATPase, H+ transporting, lysosomal accessory protein 2

Synonyms

(P)RR; 5730403E06Rik; APT6M8-9; Atp6ip2; ATP6M8-9; M8-9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033313

InnateDB Gene

IDBG-132197 (Atp6ap2)

Protein Structure

UniProt Annotation

Function

Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0002003	angiotensin maturation
GO:0006508	proteolysis
GO:0021903	rostrocaudal neural tube patterning
GO:0030177	positive regulation of Wnt signaling pathway
GO:0032914	positive regulation of transforming growth factor beta1 production
GO:0043408	regulation of MAPK cascade
GO:0048069	eye pigmentation
GO:0060323	head morphogenesis

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome