Version 5.4
Homo sapiens Protein: MARCH11
Summary
InnateDB Protein IDBP-13228.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH11
Protein Name membrane-associated ring finger (C3HC4) 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000333181
InnateDB Gene IDBG-13226 (MARCH11)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR011016 Zinc finger, RING-CH-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF12906
PF00097
PRINTS
PIRSF
SMART SM00744
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6NNE9
PhosphoSite PhosphoSite-NP_001096032
TrEMBL
UniProt Splice Variant
Entrez Gene 441061
UniGene Hs.662216
RefSeq NP_001096032
HUGO HGNC:33609
OMIM 613338
CCDS CCDS47192
HPRD
IMGT
EMBL AC016650 AC092335 BC150513 BC150514 CR590337
GenPept AAI50514 AAI50515

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca