InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bhlhe22

Summary

InnateDB Protein

IDBP-132320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bhlhe22

Protein Name

basic helix-loop-helix family, member e22

Synonyms

Beta3; Bhlhb5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026120

InnateDB Gene

IDBG-132318 (Bhlhe22)

Protein Structure

UniProt Annotation

Function

Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. {ECO:0000250, ECO:0000269PubMed:17092954, ECO:0000269PubMed:18957218, ECO:0000269PubMed:20346763}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Brain-specific, with the highest expression in the cerebellum. {ECO:0000269PubMed:12213201}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0021540	corpus callosum morphogenesis
GO:0021796	cerebral cortex regionalization
GO:0021952	central nervous system projection neuron axonogenesis
GO:0021957	corticospinal tract morphogenesis
GO:0021960	anterior commissure morphogenesis
GO:0030182	neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060040	retinal bipolar neuron differentiation
GO:0060042	retina morphogenesis in camera-type eye