Version 5.4
Mus musculus Gene: Bhlhe22
Summary
InnateDB Gene IDBG-132318.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bhlhe22
Gene Name basic helix-loop-helix family, member e22
Synonyms Beta3; Bhlhb5
Species Mus musculus
Ensembl Gene ENSMUSG00000025128
Encoded Proteins
IDBP-132320
basic helix-loop-helix family, member e22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180828:
BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. These proteins function as dimers and bind to an E-box DNA sequence (CANNTG). BHLHE22 is expressed exclusively in the central nervous system and retina (Xu et al., 2002 [PubMed 12213201]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:18054174-18057517
Strand Forward strand
Band A1
Transcripts
ENSMUST00000026120 ENSMUSP00000026120
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0021540 corpus callosum morphogenesis
GO:0021796 cerebral cortex regionalization
GO:0021952 central nervous system projection neuron axonogenesis
GO:0021957 corticospinal tract morphogenesis
GO:0021960 anterior commissure morphogenesis
GO:0030182 neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060040 retinal bipolar neuron differentiation
GO:0060042 retina morphogenesis in camera-type eye
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000180828
View Gene Order
ENSBTAG00000033173
Not yet available
Cross-References
SwissProt Q8C6A8
TrEMBL
UniProt Splice Variant
Entrez Gene 59058
UniGene Mm.149938
RefSeq NM_021560
OMIM
CCDS CCDS17253
HPRD
IMGT
MGI ID MGI:1930001
MGI Symbol Bhlhe22
EMBL AF218865 AK076228 BC053007
GenPept AAF32324 AAH53007 BAC36262
RNA Seq Atlas 59058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca