InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp51

Summary

InnateDB Protein

IDBP-132396.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp51

Protein Name

cytochrome P450, family 51

Synonyms

AI426508; Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001507

InnateDB Gene

IDBG-132394 (Cyp51)

Protein Structure

UniProt Annotation

Function

Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}. Microsome membrane {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008398	sterol 14-demethylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0033488	cholesterol biosynthetic process via 24,25-dihydrolanosterol
GO:0055114	oxidation-reduction process
GO:0070988	demethylation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle