Version 5.4
Mus musculus Gene: Cyp51
Summary
InnateDB Gene IDBG-132394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyp51
Gene Name cytochrome P450, family 51
Synonyms AI426508; Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI
Species Mus musculus
Ensembl Gene ENSMUSG00000001467
Encoded Proteins
IDBP-132396
cytochrome P450, family 51
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000001630:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:4081145-4104746
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000001507 ENSMUSP00000001507
ENSMUST00000129448
ENSMUST00000151539
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0008398 sterol 14-demethylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0033488 cholesterol biosynthetic process via 24,25-dihydrolanosterol
GO:0055114 oxidation-reduction process
GO:0070988 demethylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000001630
View Gene Order
ENSBTAG00000001992
Not yet available
Pathways
NETPATH
REACTOME
REACT_232159
Cytochrome P450 - arranged by substrate type pathway
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_198969
Activation of gene expression by SREBF (SREBP) pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_227038
Endogenous sterols pathway
REACT_208531
Cholesterol biosynthesis pathway
REACT_232343
Biological oxidations pathway
KEGG
mmu00100
Steroid biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_9405
Cholesterol biosynthesis pathway
REACT_13812
Endogenous sterols pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
REACT_209020
Endogenous sterols pathway
REACT_226409
Phase 1 - Functionalization of compounds pathway
REACT_218176
Biological oxidations pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_223232
Activation of gene expression by SREBF (SREBP) pathway
REACT_219139
Metabolism pathway
REACT_208174
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_202983
Cholesterol biosynthesis pathway
REACT_219110
Cytochrome P450 - arranged by substrate type pathway
KEGG
hsa00100
Steroid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q8K0C4
TrEMBL Q9CW87
UniProt Splice Variant
Entrez Gene 13121
UniGene Mm.140158 Mm.396259 Mm.398854 Mm.452707
RefSeq NM_020010
OMIM
CCDS CCDS19071
HPRD
IMGT
MGI ID MGI:106040
MGI Symbol Cyp51
EMBL AF166266 AF204796 AF204797 AF204798 AF204799 AF204800 AF204801 AF204802 AF204803 AF204804 AK002827 AK028355 AK028815 AK031059 AK076983 BC031813 CH466600
GenPept AAF73986 AAF74562 AAH31813 BAB22388 BAC25900 BAC26134 BAC27231 BAC36548 EDL14627
RNA Seq Atlas 13121

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca