Version 5.4
Mus musculus Protein: Nup43
Summary
InnateDB Protein IDBP-132441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nup43
Protein Name nucleoporin 43
Synonyms 2610016K01Rik; 2610529I12Rik; AA409950; p42;
Species Mus musculus
Ensembl Protein ENSMUSP00000046732
InnateDB Gene IDBG-132439 (Nup43)
Protein Structure
UniProt Annotation
Function Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity). {ECO:0000250}.
Subcellular Localization Chromosome, centromere, kinetochore {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0015031 protein transport
GO:0051028 mRNA transport
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0031080 nuclear pore outer ring
Protein Structure and Domains
PDB ID MGI:1917162
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P59235
PhosphoSite PhosphoSite-
TrEMBL Q8BT98
UniProt Splice Variant
Entrez Gene 69912
UniGene Mm.460316
RefSeq NP_663752
MGI ID
MGI Symbol Nup43
OMIM
CCDS CCDS48493
HPRD
IMGT
EMBL AC156391 AK012191 AK090019
GenPept BAC25359 BAC41049

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca