InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctnnd2

Summary

InnateDB Protein

IDBP-132444.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctnnd2

Protein Name

catenin (cadherin associated protein), delta 2

Synonyms

Catnd2; neurojugin; Nprap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080427

InnateDB Gene

IDBG-132442 (Ctnnd2)

Protein Structure

UniProt Annotation

Function

May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33. {ECO:0000269PubMed:15282317, ECO:0000269PubMed:9971746}.

Subcellular Localization

Nucleus. Cell junction, adherens junction. Note=Colocalizes with CDK5 in the cell body of neuronal cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in neurons and glial cells. Isoform 2 was found to be the most predominant isoform in various brain regions. Expressed at neuromuscular junctions. {ECO:0000269PubMed:10753311, ECO:0000269PubMed:15282317}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0001763	morphogenesis of a branching structure
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007612	learning
GO:0016337	single organismal cell-cell adhesion
GO:0048167	regulation of synaptic plasticity