InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syt4

Summary

InnateDB Protein

IDBP-132572.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syt4

Protein Name

synaptotagmin IV

Synonyms

SytIV;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025110

InnateDB Gene

IDBG-132570 (Syt4)

Protein Structure

UniProt Annotation

Function

May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in many regions of the nervous system but is undetectable in extra neural tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0001786	phosphatidylserine binding
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030276	clathrin binding

Biological Process

GO:0006887	exocytosis
GO:0007269	neurotransmitter secretion
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0031339	negative regulation of vesicle fusion
GO:0045955	negative regulation of calcium ion-dependent exocytosis
GO:0048489	synaptic vesicle transport

Cellular Component

GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031045	dense core granule
GO:0043005	neuron projection
GO:0048471	perinuclear region of cytoplasm