InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: March6

Summary

InnateDB Protein

IDBP-132761.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

March6

Protein Name

membrane-associated ring finger (C3HC4) 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087694

InnateDB Gene

IDBG-132757 (March6)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019899	enzyme binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0046872	metal ion binding