Version 5.4
Mus musculus Gene: March6
Summary
InnateDB Gene IDBG-132757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol March6
Gene Name membrane-associated ring finger (C3HC4) 6
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000039100
Encoded Proteins
IDBP-132761
membrane-associated ring finger (C3HC4) 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145495:
This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:31455899-31531037
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000090227 ENSMUSP00000087694
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019899 enzyme binding
GO:0031624 ubiquitin conjugating enzyme binding
GO:0046872 metal ion binding
Biological Process
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145495
View Gene Order
ENSBTAG00000003536
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q6ZQ89
TrEMBL Q8K2D5
UniProt Splice Variant
Entrez Gene 223455
UniGene Mm.272185 Mm.409542 Mm.420148 Mm.424070 Mm.474635
RefSeq NM_172606
OMIM
CCDS CCDS37054
HPRD
IMGT
MGI ID MGI:2442773
MGI Symbol March6
EMBL AK042980 AK089827 AK129169 BC031721 BC037454 BC048816 BC059190
GenPept AAH31721 AAH37454 AAH48816 AAH59190 BAC31427 BAC40971 BAC97979
RNA Seq Atlas 223455

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca