InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epha7

Summary

InnateDB Protein

IDBP-132774.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epha7

Protein Name

Eph receptor A7

Synonyms

Cek11; Ebk; Ehk3; Hek11; Mdk1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079735

InnateDB Gene

IDBG-132772 (Epha7)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties. {ECO:0000269PubMed:15902206, ECO:0000269PubMed:15996548, ECO:0000269PubMed:16301174}.

Subcellular Localization

Cell membrane {ECO:0000305PubMed:11089974}; Single-pass type I membrane protein {ECO:0000305PubMed:11089974}.

Disease Associations

Tissue Specificity

Widely expressed in embryo. In adult, expression restricted to hippocampus, testis and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005004	GPI-linked ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0045499	chemorepellent activity
GO:0046875	ephrin receptor binding

Biological Process

GO:0007420	brain development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0022407	regulation of cell-cell adhesion
GO:0031290	retinal ganglion cell axon guidance
GO:0031952	regulation of protein autophosphorylation
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0048013	ephrin receptor signaling pathway
GO:0048755	branching morphogenesis of a nerve
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050919	negative chemotaxis
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0030425	dendrite
GO:0031594	neuromuscular junction
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:95276

InterPro

IPR001090 Ephrin receptor ligand binding domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal

PFAM

PF01404
PF00041
PF01108

PRINTS

PIRSF

SMART

SM00615
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61772