InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Epha7

Summary

InnateDB Gene

IDBG-132772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epha7

Gene Name

Eph receptor A7

Synonyms

Cek11; Ebk; Ehk3; Hek11; Mdk1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028289

Encoded Proteins

IDBP-132774

Eph receptor A7

IDBP-132776

Eph receptor A7

IDBP-265049

Eph receptor A7

IDBP-265051

Eph receptor A7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135333:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:28813131-28967499

Strand

Forward strand

Band

Transcripts

ENSMUST00000080934	ENSMUSP00000079735
ENSMUST00000029964	ENSMUSP00000029964
ENSMUST00000108194	ENSMUSP00000103829
ENSMUST00000108191	ENSMUSP00000103826
ENSMUST00000149030
ENSMUST00000136827
ENSMUST00000129029
ENSMUST00000129912

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0045499	chemorepellent activity
GO:0046875	ephrin receptor binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007420	brain development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0022407	regulation of cell-cell adhesion
GO:0031290	retinal ganglion cell axon guidance
GO:0031952	regulation of protein autophosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0048013	ephrin receptor signaling pathway
GO:0048755	branching morphogenesis of a nerve
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050919	negative chemotaxis
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0030425	dendrite
GO:0031594	neuromuscular junction
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane