InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ing1

Summary

InnateDB Protein

IDBP-132804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ing1

Protein Name

inhibitor of growth family, member 1

Synonyms

2610028J21Rik; AA407184; AI875420; mING1h; p33Ing1; p37Ing1b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062593

InnateDB Gene

IDBG-132802 (Ing1)

Protein Structure

UniProt Annotation

Function

Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor. {ECO:0000269PubMed:10542254}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

In the adult, widely expressed with highest levels in thymus and testis. {ECO:0000269PubMed:10542254}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding

Biological Process

GO:0006606	protein import into nucleus
GO:0007049	cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0010941	regulation of cell death
GO:0016568	chromatin modification
GO:0045893	positive regulation of transcription, DNA-templated