InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Litaf

Summary

InnateDB Protein

IDBP-132810.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Litaf

Protein Name

LPS-induced TN factor

Synonyms

3222402J11Rik; C85531; N4WBP3; TBX1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023143

InnateDB Gene

IDBG-132808 (Litaf)

Protein Structure

UniProt Annotation

Function

Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. {ECO:0000269PubMed:12355436, ECO:0000269PubMed:15025820}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with membranes of lysosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in liver. {ECO:0000269PubMed:12355436, ECO:0000269PubMed:15025820}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0050699	WW domain binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007568	aging
GO:0032496	response to lipopolysaccharide
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0043231	intracellular membrane-bounded organelle