Version 5.4
Mus musculus Gene: Litaf
Summary
InnateDB Gene IDBG-132808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Litaf
Gene Name LPS-induced TN factor
Synonyms 3222402J11Rik; C85531; N4WBP3; TBX1
Species Mus musculus
Ensembl Gene ENSMUSG00000022500
Encoded Proteins
IDBP-132810
LPS-induced TN factor
IDBP-401671
LPS-induced TN factor
IDBP-542722
LPS-induced TN factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000189067:
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008]
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget\'s disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:10959275-11066157
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000023143 ENSMUSP00000023143
ENSMUST00000117360 ENSMUSP00000112667
ENSMUST00000162323 ENSMUSP00000123948
ENSMUST00000140170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0050699 WW domain binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007568 aging
GO:0032496 response to lipopolysaccharide
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000189067
View Gene Order
ENSBTAG00000005622
Not yet available
Cross-References
SwissProt Q9JLJ0
TrEMBL E0CYR5
UniProt Splice Variant
Entrez Gene 56722
UniGene Mm.294753 Mm.466843
RefSeq NM_019980 XM_006522427
OMIM
CCDS CCDS27958
HPRD
IMGT
MGI ID MGI:1929512
MGI Symbol Litaf
EMBL AC164093 AF171100 AF220207 AF230522 AK018578 AK076162 AK151053 AK159533 BC018559
GenPept AAF27312 AAG44246 AAH18559 AAO49168 BAB31289 BAC36228 BAE30070 BAE35161
RNA Seq Atlas 56722

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca