InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elmo1

Summary

InnateDB Protein

IDBP-132931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elmo1

Protein Name

engulfment and cell motility 1, ced-12 homolog (C. elegans)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072334

InnateDB Gene

IDBG-132929 (Elmo1)

Protein Structure

UniProt Annotation

Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0006909	phagocytosis
GO:0006911	phagocytosis, engulfment
GO:0006915	apoptotic process
GO:0006928	cellular component movement
GO:0016601	Rac protein signal transduction
GO:0030029	actin filament-based process
GO:0030036	actin cytoskeleton organization