InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Elmo1

Summary

InnateDB Gene

IDBG-132929.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elmo1

Gene Name

engulfment and cell motility 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041112

Encoded Proteins

IDBP-132931

engulfment and cell motility 1, ced-12 homolog (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155849:
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:20090596-20606528

Strand

Forward strand

Band

Transcripts

ENSMUST00000072519	ENSMUSP00000072334
ENSMUST00000180626
ENSMUST00000180767
ENSMUST00000181429

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0006909	phagocytosis
GO:0006911	phagocytosis, engulfment
GO:0006915	apoptotic process
GO:0006928	cellular component movement
GO:0016601	Rac protein signal transduction
GO:0030029	actin filament-based process
GO:0030036	actin cytoskeleton organization