InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hltf

Summary

InnateDB Protein

IDBP-133288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hltf

Protein Name

helicase-like transcription factor

Synonyms

AF010600; BC057116; P113; Smarca3; Snf2l3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002502

InnateDB Gene

IDBG-133286 (Hltf)

Protein Structure

UniProt Annotation

Function

Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269PubMed:9427542}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Nuclear localization is stimulated by progesterone. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269PubMed:9126292}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016874	ligase activity
GO:0016887	ATPase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0016567	protein ubiquitination
GO:0016568	chromatin modification

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1196437

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR001841 Zinc finger, RING-type
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014905 HIP116, Rad5p N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF13639
PF14634
PF08797

PRINTS

PIRSF

SMART

SM00490
SM00184
SM00487
SM00910

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6PCN7