InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hltf

Summary

InnateDB Gene

IDBG-133286.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hltf

Gene Name

helicase-like transcription factor

Synonyms

AF010600; BC057116; P113; Smarca3; Snf2l3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002428

Encoded Proteins

IDBP-133288

helicase-like transcription factor

IDBP-535131

helicase-like transcription factor

IDBP-534593

helicase-like transcription factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071794:
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:20057811-20118490

Strand

Forward strand

Band

Transcripts

ENSMUST00000002502	ENSMUSP00000002502
ENSMUST00000143005	ENSMUSP00000116570
ENSMUST00000128127
ENSMUST00000154233
ENSMUST00000145853	ENSMUSP00000118775
ENSMUST00000155635

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016874	ligase activity
GO:0016887	ATPase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0016567	protein ubiquitination
GO:0016568	chromatin modification

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000071794

View Gene Order

ENSBTAG00000019704

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_56

Prolactin pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.209650 Mm.347615 Mm.403454 Mm.408488 Mm.472314 Mm.487777

RefSeq

NM_009210 NM_144959 XM_006535428 XM_006535429

OMIM

CCDS

CCDS17261

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas