InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbll1

Summary

InnateDB Protein

IDBP-133315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbll1

Protein Name

Casitas B-lineage lymphoma-like 1

Synonyms

AI467391; c-Cbl-like; Hakai;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063266

InnateDB Gene

IDBG-133313 (Cbll1)

Protein Structure

UniProt Annotation

Function

Promotes ubiquitination of several tyrosine- phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. {ECO:0000269PubMed:11836526, ECO:0000269PubMed:22252131}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269PubMed:11836526}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042802	identical protein binding

Biological Process

GO:0007162	negative regulation of cell adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0016567	protein ubiquitination
GO:0030335	positive regulation of cell migration
GO:0045807	positive regulation of endocytosis