InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Suv39h2

Summary

InnateDB Protein

IDBP-133334.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Suv39h2

Protein Name

suppressor of variegation 3-9 homolog 2 (Drosophila)

Synonyms

4930507K23Rik; AA536750; D030054H19Rik; D2Ertd544e; KMT1B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027956

InnateDB Gene

IDBG-133332 (Suv39h2)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269PubMed:11701123, ECO:0000269PubMed:14690609, ECO:0000269PubMed:14690610, ECO:0000269PubMed:14702045, ECO:0000269PubMed:24413057}.

Subcellular Localization

Nucleus. Chromosome. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin during most stages of spermato- and spermiogenesis. Predominantly accumulates at the sex chromosomes present at the XY body.

Disease Associations

Tissue Specificity

Testis specific; predominant expression in type B spermatogonia and preleptotene spermatocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0008276	protein methyltransferase activity
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)

Biological Process

GO:0006333	chromatin assembly or disassembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0007140	male meiosis
GO:0030154	cell differentiation
GO:0034968	histone lysine methylation
GO:0036123	histone H3-K9 dimethylation
GO:0036124	histone H3-K9 trimethylation
GO:0042754	negative regulation of circadian rhythm
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051567	histone H3-K9 methylation

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005720	nuclear heterochromatin

Protein Structure and Domains

PDB ID

MGI:1890396

InterPro

IPR000953 Chromo domain/shadow
IPR001214 SET domain
IPR003606 Pre-SET zinc-binding sub-group
IPR003616 Post-SET domain
IPR007728 Pre-SET domain
IPR011381 Histone H3-K9 methyltransferase
IPR016197 Chromo domain-like
IPR023780 Chromo domain

PFAM

PF00856
PF05033
PF00385

PRINTS

PIRSF

PIRSF009343

SMART

SM00298
SM00317
SM00468
SM00508

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt