InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shprh

Summary

InnateDB Protein

IDBP-133392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shprh

Protein Name

SNF2 histone linker PHD RING helicase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039422

InnateDB Gene

IDBG-488459 (Shprh)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63' (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Broadly expressed (at protein level). {ECO:0000269PubMed:12837266}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0006281	DNA repair
GO:0006334	nucleosome assembly
GO:0016567	protein ubiquitination

Cellular Component

GO:0000786	nucleosome
GO:0005575	cellular_component
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:1917581

InterPro

IPR000330 SNF2-related
IPR001202 WW domain
IPR001251 CRAL-TRIO domain
IPR001650 Helicase, C-terminal
IPR001841 Zinc finger, RING-type
IPR001965 Zinc finger, PHD-type
IPR005818 Linker histone H1/H5, domain H15
IPR011011 Zinc finger, FYVE/PHD-type
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM