Version 5.4
Mus musculus Protein: Serac1
Summary
InnateDB Protein IDBP-133433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serac1
Protein Name serine active site containing 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000095043
InnateDB Gene IDBG-133431 (Serac1)
Protein Structure
UniProt Annotation
Function Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation- acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface. {ECO:0000250}.
Disease Associations
Tissue Specificity Testis. {ECO:0000269PubMed:15722415}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0006505 GPI anchor metabolic process
GO:0006886 intracellular protein transport
GO:0008654 phospholipid biosynthetic process
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID MGI:2447813
InterPro IPR012908 GPI inositol-deacylase PGAP1-like
IPR016024 Armadillo-type fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF07819
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U213
PhosphoSite PhosphoSite-BAB31833
TrEMBL
UniProt Splice Variant
Entrez Gene 321007
UniGene Mm.5548
RefSeq NP_001104487
MGI ID
MGI Symbol Serac1
OMIM
CCDS CCDS49933
HPRD
IMGT
EMBL AK019677 AK154605 AK155571 AK162246 AK170498 BC119594 BC119595
GenPept AAI19595 AAI19596 BAB31833 BAE32707 BAE33329 BAE36813 BAE41837

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca