Version 5.4
Mus musculus Gene: Serac1
Summary
InnateDB Gene IDBG-133431.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serac1
Gene Name serine active site containing 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000015659
Encoded Proteins
IDBP-133433
serine active site containing 1
IDBP-133435
serine active site containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122335:
The protein encoded by this gene is a phosphatidylglycerol remodeling protein found at the interface of mitochondria and endoplasmic reticula, where it mediates phospholipid exchange. The encoded protein plays a major role in mitochondrial function and intracellular cholesterol trafficking. Defects in this gene are a cause of 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:6042196-6079741
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000097432 ENSMUSP00000095043
ENSMUST00000024570 ENSMUSP00000024570
ENSMUST00000153325
ENSMUST00000144284
ENSMUST00000139542
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0006505 GPI anchor metabolic process
GO:0006886 intracellular protein transport
GO:0008654 phospholipid biosynthetic process
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000122335
View Gene Order
ENSBTAG00000011509
Not yet available
Cross-References
SwissProt Q3U213
TrEMBL
UniProt Splice Variant
Entrez Gene 321007
UniGene Mm.5548
RefSeq NM_001111017 NM_177311 XM_006523237
OMIM
CCDS CCDS28366 CCDS49933
HPRD
IMGT
MGI ID MGI:2447813
MGI Symbol Serac1
EMBL AK019677 AK154605 AK155571 AK162246 AK170498 BC119594 BC119595
GenPept AAI19595 AAI19596 BAB31833 BAE32707 BAE33329 BAE36813 BAE41837
RNA Seq Atlas 321007

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca