InnateDB Protein
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IDBP-133545.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gtf2h5
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Protein Name
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general transcription factor IIH, polypeptide 5
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Synonyms
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2700017P07Rik; 2810432H05Rik; D17Wsu155e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000040355
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InnateDB Gene
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IDBG-133543 (Gtf2h5)
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Protein Structure
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Function |
Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
GO:0006289
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nucleotide-excision repair
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GO:0006294
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nucleotide-excision repair, preincision complex assembly
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006362
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transcription elongation from RNA polymerase I promoter
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GO:0006364
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rRNA processing
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GO:0071480
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cellular response to gamma radiation
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Cellular Component |
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PDB ID |
MGI:107227
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InterPro |
IPR009400
TFIIH subunit TTDA/Tfb5
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PFAM |
PF06331
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K2X8
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66467
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UniGene |
Mm.482208
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RefSeq |
NP_852057
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MGI ID |
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MGI Symbol |
Gtf2h5
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OMIM |
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CCDS |
CCDS37423
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HPRD |
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IMGT |
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EMBL |
AK003547
AK003579
AK011281
AK012257
AK013225
BC029238
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GenPept |
AAH29238
BAC25038
BAC25043
BAC25328
BAC25362
BAC25398
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