InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Maoa

Summary

InnateDB Protein

IDBP-133559.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Maoa

Protein Name

monoamine oxidase A

Synonyms

1110061B18Rik; AA407771;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026013

InnateDB Gene

IDBG-133557 (Maoa)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008131	primary amine oxidase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0042135	neurotransmitter catabolic process
GO:0042420	dopamine catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96915

InterPro

IPR001613 Flavin amine oxidase
IPR002937 Amine oxidase
IPR002938 Monooxygenase, FAD-binding
IPR003953 FAD binding domain
IPR006076 FAD dependent oxidoreductase

PFAM

PF01593
PF01494
PF00890
PF01266

PRINTS

PR00757

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64133