InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prkar2b

Summary

InnateDB Protein

IDBP-133759.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkar2b

Protein Name

protein kinase, cAMP dependent regulatory, type II beta

Synonyms

AI451071; AW061005; Pkarb2; PKARIIbeta; RII(beta);

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039797

InnateDB Gene

IDBG-133755 (Prkar2b)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004862	cAMP-dependent protein kinase inhibitor activity
GO:0005515	protein binding
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0019901	protein kinase binding
GO:0030552	cAMP binding
GO:0031625	ubiquitin protein ligase binding
GO:0034236	protein kinase A catalytic subunit binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006631	fatty acid metabolic process
GO:0007612	learning
GO:2000480	negative regulation of cAMP-dependent protein kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0005952	cAMP-dependent protein kinase complex
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0097546	ciliary base

Protein Structure and Domains

PDB ID

MGI:97760

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR002373 cAMP/cGMP-dependent protein kinase
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR012198 cAMP-dependent protein kinase regulatory subunit
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF02197

PRINTS

PR00103

PIRSF

PIRSF000548

SMART

SM00100
SM00394

TIGRFAMs

Post-translational Modifications

Modification

Cross-References