InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bin1

Summary

InnateDB Protein

IDBP-133767.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bin1

Protein Name

bridging integrator 1

Synonyms

ALP-1; Amphl; BRAMP-2; SH3P9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025239

InnateDB Gene

IDBG-133763 (Bin1)

Protein Structure

UniProt Annotation

Function

May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed mainly in the brain. Isoform 2 is widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity
GO:0048156	tau protein binding
GO:0051020	GTPase binding

Biological Process

GO:0006897	endocytosis
GO:0042692	muscle cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0045664	regulation of neuron differentiation
GO:0045807	positive regulation of endocytosis
GO:0048711	positive regulation of astrocyte differentiation
GO:0060988	lipid tube assembly
GO:0071156	regulation of cell cycle arrest

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0008021	synaptic vesicle
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0030424	axon
GO:0031674	I band
GO:0033268	node of Ranvier
GO:0043194	axon initial segment
GO:0043196	varicosity
GO:0043679	axon terminus
GO:0044300	cerebellar mossy fiber
GO:0060987	lipid tube