InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bin1

Summary

InnateDB Gene

IDBG-133763.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bin1

Gene Name

bridging integrator 1

Synonyms

ALP-1; Amphl; BRAMP-2; SH3P9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024381

Encoded Proteins

IDBP-133765

bridging integrator 1

IDBP-133767

bridging integrator 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136717:
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:32377217-32435736

Strand

Forward strand

Band

Transcripts

ENSMUST00000091967	ENSMUSP00000089590
ENSMUST00000025239	ENSMUSP00000025239

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity
GO:0048156	tau protein binding
GO:0051020	GTPase binding

Biological Process

GO:0006897	endocytosis
GO:0030100	regulation of endocytosis
GO:0042692	muscle cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0045664	regulation of neuron differentiation
GO:0045807	positive regulation of endocytosis
GO:0048711	positive regulation of astrocyte differentiation
GO:0060988	lipid tube assembly
GO:0071156	regulation of cell cycle arrest

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0008021	synaptic vesicle
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0030424	axon
GO:0031674	I band
GO:0033268	node of Ranvier
GO:0043194	axon initial segment
GO:0043196	varicosity
GO:0043679	axon terminus
GO:0044300	cerebellar mossy fiber
GO:0060987	lipid tube

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000136717

View Gene Order

ENSBTAG00000019177

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

p73pathway

p73 transcription factor network

arf6_traffickingpathway

Arf6 trafficking events

Cross-References

SwissProt

O08539

TrEMBL

Q6P1B9 Q8C5M9

UniProt Splice Variant

Entrez Gene

30948

UniGene

Mm.466748

RefSeq

NM_001083334 NM_009668

OMIM

CCDS

CCDS29119 CCDS37755

HPRD

IMGT

MGI ID

MGI:108092

MGI Symbol

Bin1

EMBL

AC126026 AK077987 BC065160 U60884 U86405

GenPept

AAC52661 AAC53318 AAH65160 BAC37090

RNA Seq Atlas

30948