Version 5.4
Mus musculus Protein: Sytl3
Summary
InnateDB Protein IDBP-133925.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sytl3
Protein Name synaptotagmin-like 3
Synonyms A430092N21; mFLJ00307; Slp3; Slp3-a; Slp3-b;
Species Mus musculus
Ensembl Protein ENSMUSP00000095041
InnateDB Gene IDBG-133919 (Sytl3)
Protein Structure
UniProt Annotation
Function May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions.
Subcellular Localization Endomembrane system; Peripheral membrane protein.
Disease Associations
Tissue Specificity Highly expressed in spleen and lung. Detected at lower levels in heart and testis. {ECO:0000269PubMed:11327731}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008270 zinc ion binding
GO:0017137 Rab GTPase binding
GO:0042043 neurexin family protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
Cellular Component
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0019897 extrinsic component of plasma membrane
Protein Structure and Domains
PDB ID MGI:1933367
InterPro IPR000008 C2 domain
IPR010911 Zinc finger, FYVE-type
IPR011011 Zinc finger, FYVE/PHD-type
PFAM PF00168
PF02318
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99N48
PhosphoSite PhosphoSite-Q99N48
TrEMBL Q3U0P9
UniProt Splice Variant
Entrez Gene 83672
UniGene
RefSeq NP_113572
MGI ID
MGI Symbol Sytl3
OMIM
CCDS CCDS28372
HPRD
IMGT
EMBL AB050743 AB057758 AB057764 AB057765 AB057766 AC167249 AC168090 AK079850 AK156673 BC022608 BC106102
GenPept AAH22608 AAI06103 BAB32653 BAB41086 BAB41092 BAB41093 BAB41094 BAC37766 BAE33803

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca