InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phyh

Summary

InnateDB Protein

IDBP-133989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phyh

Protein Name

phytanoyl-CoA hydroxylase

Synonyms

AI256161; AI265699; Lnap1; PAHX;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027975

InnateDB Gene

IDBG-133987 (Phyh)

Protein Structure

UniProt Annotation

Function

Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.

Subcellular Localization

Peroxisome.

Disease Associations

Note=Defects in Phyh are the cause of lupus nephritis, a severe autoimmune disease. Phyh could be involved in a reaction against the progression of the disease, because its expression is low in the early stage of the disease in the renal cortex of MRL/lpr mice.

Tissue Specificity

Ubiquitously expressed in all tissues with significant levels detected in the embryonic and neonatal heart and liver. In the adult, significant levels are detected in the liver, kidney, heart, gut, brain and aorta. {ECO:0000269PubMed:10686344}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0031418	L-ascorbic acid binding
GO:0046872	metal ion binding
GO:0048037	cofactor binding
GO:0048244	phytanoyl-CoA dioxygenase activity