Version 5.4
| Homo sapiens Protein: CNTN6 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-13402.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | CNTN6 | ||||||||
| Protein Name | contactin 6 | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000341882 | ||||||||
| InnateDB Gene | IDBG-13400 (CNTN6) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR003961 Fibronectin, type III IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013106 Immunoglobulin V-set domain IPR013151 Immunoglobulin |
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| PFAM |
PF00041
PF01108 PF07679 PF07686 PF00047 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00408
SM00409 SM00060 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9UQ52 | ||||||||
| PhosphoSite | PhosphoSite-Q9UQ52 | ||||||||
| TrEMBL | F5H752 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 27255 | ||||||||
| UniGene | Hs.387300 | ||||||||
| RefSeq | NP_055276 | ||||||||
| HUGO | HGNC:2176 | ||||||||
| OMIM | 607220 | ||||||||
| CCDS | CCDS2557 | ||||||||
| HPRD | 06242 | ||||||||
| IMGT | |||||||||
| EMBL | AB003592 AC026214 AC027123 AC034192 BC113118 CH471055 | ||||||||
| GenPept | AAI13119 BAA82612 EAW63871 EAW63872 | ||||||||