Version 5.4
Mus musculus Protein: Hist1h2bl
Summary
InnateDB Protein IDBP-134089.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hist1h2bl
Protein Name histone cluster 1, H2bl
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000089350
InnateDB Gene IDBG-704109 (Hist1h2bl)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
Protein Structure and Domains
PDB ID MGI:2448403
InterPro IPR000558 Histone H2B
IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS PR00621
PIRSF
SMART SM00427
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10853
PhosphoSite PhosphoSite-P10853
TrEMBL A0JLV3
UniProt Splice Variant
Entrez Gene 319187
UniGene Mm.377880
RefSeq NP_835506
MGI ID
MGI Symbol Hist1h2bl
OMIM
CCDS CCDS26287
HPRD
IMGT
EMBL AL589651 AL589879 AL590614 AY158927 AY158929 AY158932 AY158935 BC115792 U62669 X05862
GenPept AAB04762 AAI15793 AAO06237 AAO06239 AAO06242 AAO06245 CAA29290 CAI24103 CAI24111 CAI25462 CAI25467 CAI26130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca