InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Optn

Summary

InnateDB Protein

IDBP-134124.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Optn

Protein Name

optineurin

Synonyms

4930441O07Rik; FIP2; HYPL; NRP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027986

InnateDB Gene

IDBG-134122 (Optn)

Protein Structure

UniProt Annotation

Function

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Golgi apparatus {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Recycling endosome {ECO:0000250}. Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

In eye, it is expressed in anterior segment, retina, and optic nerve blood vessels (at protein level). Highly expressed in adult liver, heart and testis. {ECO:0000269PubMed:15607428}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0000042	protein targeting to Golgi
GO:0001920	negative regulation of receptor recycling
GO:0007030	Golgi organization
GO:0016236	macroautophagy
GO:0034613	cellular protein localization
GO:0043001	Golgi to plasma membrane protein transport
GO:0050829	defense response to Gram-negative bacterium
GO:0090161	Golgi ribbon formation