InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Optn

Summary

InnateDB Gene

IDBG-134122.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Optn

Gene Name

optineurin

Synonyms

4930441O07Rik; FIP2; HYPL; NRP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026672

Encoded Proteins

IDBP-134124

optineurin

IDBP-250613

optineurin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20174559

[Homo sapiens] OPTN (optineurin) has a role in the inhibition of virus-triggered IFNB1 induction.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123240:
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:5020642-5064051

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027986	ENSMUSP00000027986
ENSMUST00000114996	ENSMUSP00000110648
ENSMUST00000125203
ENSMUST00000145501
ENSMUST00000143809

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0000042	protein targeting to Golgi
GO:0001920	negative regulation of receptor recycling
GO:0007030	Golgi organization
GO:0016236	macroautophagy
GO:0034613	cellular protein localization
GO:0043001	Golgi to plasma membrane protein transport
GO:0050829	defense response to Gram-negative bacterium
GO:0090161	Golgi ribbon formation