InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ntan1

Summary

InnateDB Protein

IDBP-134146.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ntan1

Protein Name

N-terminal Asn amidase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023362

InnateDB Gene

IDBG-134144 (Ntan1)

Protein Structure

UniProt Annotation

Function

Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008418	protein-N-terminal asparagine amidohydrolase activity

Biological Process

GO:0007613	memory
GO:0008152	metabolic process
GO:0008344	adult locomotory behavior

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:108471

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64311

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

18203

UniGene

Mm.472295

RefSeq

NP_035076

MGI ID

MGI Symbol

Ntan1

OMIM

CCDS

CCDS27969

HPRD

IMGT

EMBL

BC030172 U57691 U57692

GenPept

AAB66490 AAC52885 AAH30172