Version 5.4
Mus musculus Protein: Tnfsf10
Summary
InnateDB Protein IDBP-134364.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfsf10
Protein Name tumor necrosis factor (ligand) superfamily, member 10
Synonyms A330042I21Rik; AI448571; APO-2L; Ly81; TL2; Trail;
Species Mus musculus
Ensembl Protein ENSMUSP00000040271
InnateDB Gene IDBG-134362 (Tnfsf10)
Protein Structure
UniProt Annotation
Function Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widespread.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0032813 tumor necrosis factor receptor superfamily binding
Biological Process
GO:0006955 immune response
GO:0008584 male gonad development
GO:0032868 response to insulin
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:107414
InterPro IPR006052 Tumour necrosis factor domain
IPR008983 Tumour necrosis factor-like domain
IPR017355 Tumour necrosis factor ligand 10/11
PFAM PF00229
PRINTS
PIRSF PIRSF038013
SMART SM00207
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50592
PhosphoSite PhosphoSite-
TrEMBL Q9EQS7
UniProt Splice Variant
Entrez Gene 22035
UniGene
RefSeq NP_033451
MGI ID
MGI Symbol Tnfsf10
OMIM
CCDS CCDS17272
HPRD
IMGT
EMBL AB052771 AK142960 AK153581 BC138807 BC138808 CH466530 U37522
GenPept AAC52345 AAI38808 AAI38809 BAB19680 BAE25231 BAE32108 EDL34926

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca