InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnfsf10

Summary

InnateDB Gene

IDBG-134362.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfsf10

Gene Name

tumor necrosis factor (ligand) superfamily, member 10

Synonyms

A330042I21Rik; AI448571; APO-2L; Ly81; TL2; Trail

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039304

Encoded Proteins

IDBP-134364

tumor necrosis factor (ligand) superfamily, member 10

IDBP-627905

tumor necrosis factor (ligand) superfamily, member 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23498957

[Homo sapiens] TNFSF10 is targeted by human cytomegalovirus glycoprotein to protect infected cells from natural killer cell cytotoxicity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121858:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:27317028-27342427

Strand

Forward strand

Band

Transcripts

ENSMUST00000046383	ENSMUSP00000040271
ENSMUST00000174840	ENSMUSP00000133917

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0032813	tumor necrosis factor receptor superfamily binding

Biological Process

GO:0006955	immune response
GO:0008584	male gonad development
GO:0032868	response to insulin
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway