InnateDB Protein
|
IDBP-13440.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ANO2
|
Protein Name
|
anoctamin 2
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000314048
|
InnateDB Gene
|
IDBG-13438 (ANO2)
|
Protein Structure
|
|
Function |
Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO:0000269PubMed:19474308, ECO:0000269PubMed:20056604, ECO:0000269PubMed:21890523, ECO:0000269PubMed:21984732}.
|
Subcellular Localization |
Cell membrane {ECO:0000269PubMed:20056604}; Multi-pass membrane protein {ECO:0000269PubMed:20056604}.
|
Disease Associations |
|
Tissue Specificity |
Retina, especially in the photoreceptor synaptic terminals. {ECO:0000269PubMed:19474308}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005229
|
intracellular calcium activated chloride channel activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR007632
Anoctamin
|
PFAM |
PF04547
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9NQ90
|
PhosphoSite |
PhosphoSite-Q9NQ90
|
TrEMBL |
Q69YW4
|
UniProt Splice Variant |
|
Entrez Gene |
57101
|
UniGene |
|
RefSeq |
XP_006719052
|
HUGO |
HGNC:1183
|
OMIM |
610109
|
CCDS |
|
HPRD |
11634
|
IMGT |
|
EMBL |
AC006431
AC006560
AC137627
AJ272204
AK024010
AL137419
FJ384095
|
GenPept |
ACL36050
BAB14773
CAC01125
CAH10704
|
|
|