InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amotl1

Summary

InnateDB Protein

IDBP-134498.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amotl1

Protein Name

angiomotin-like 1

Synonyms

2310010G08Rik; 2310067L22Rik; 4932416D09Rik; JEAP; mFLJ00155;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013220

InnateDB Gene

IDBG-134496 (Amotl1)

Protein Structure

UniProt Annotation

Function

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction {ECO:0000269PubMed:11733531}.

Disease Associations

Tissue Specificity

Expressed in exocrine glands, including pancreas, submandibular gland, lacrimal gland, parotid gland and sublingual gland (at protein level). {ECO:0000269PubMed:11733531}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0003365	establishment of cell polarity involved in ameboidal cell migration
GO:0016055	Wnt signaling pathway
GO:0035329	hippo signaling
GO:0043536	positive regulation of blood vessel endothelial cell migration

Cellular Component

GO:0005737	cytoplasm
GO:0005923	tight junction
GO:0008180	COP9 signalosome
GO:0016324	apical plasma membrane
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0031410	cytoplasmic vesicle