Version 5.4
Mus musculus Gene: Amotl1
Summary
InnateDB Gene IDBG-134496.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Amotl1
Gene Name angiomotin-like 1
Synonyms 2310010G08Rik; 2310067L22Rik; 4932416D09Rik; JEAP; mFLJ00155
Species Mus musculus
Ensembl Gene ENSMUSG00000013076
Encoded Proteins
IDBP-134498
angiomotin-like 1
IDBP-535428
angiomotin-like 1
IDBP-535123
angiomotin-like 1
IDBP-538620
angiomotin-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166025:
The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:14541966-14615483
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000013220 ENSMUSP00000013220
ENSMUST00000160770 ENSMUSP00000124281
ENSMUST00000161171
ENSMUST00000162901 ENSMUSP00000123983
ENSMUST00000162802 ENSMUSP00000124559
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0003365 establishment of cell polarity involved in ameboidal cell migration
GO:0016055 Wnt signaling pathway
GO:0035329 hippo signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
Cellular Component
GO:0005737 cytoplasm
GO:0005923 tight junction
GO:0008180 COP9 signalosome
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166025
View Gene Order
ENSBTAG00000018945
Not yet available
Pathways
NETPATH
REACTOME
REACT_196537
Signaling by Hippo pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
REACT_214353
Signal Transduction pathway
REACT_217897
Signaling by Hippo pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt Q9D4H4
TrEMBL E0CY12 E0CYQ3
UniProt Splice Variant
Entrez Gene 75723
UniGene Mm.159552
RefSeq NM_001081395 XM_006510666 XM_006510667 XM_006510668 XM_006510669 XM_006510670
OMIM
CCDS CCDS40535
HPRD
IMGT
MGI ID MGI:1922973
MGI Symbol Amotl1
EMBL AK016526 AK220238 BC151000 BC151004 BC151007 CT030247 CT485607
GenPept AAI51001 AAI51005 AAI51008 BAB30287 BAD90163
RNA Seq Atlas 75723

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca