InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cul4a

Summary

InnateDB Protein

IDBP-134597.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cul4a

Protein Name

cullin 4A

Synonyms

2810470J21Rik; AW495282;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016680

InnateDB Gene

IDBG-134595 (Cul4a)

Protein Structure

UniProt Annotation

Function

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 230 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	230 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006281	DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008284	positive regulation of cell proliferation
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0030097	hemopoiesis
GO:0030853	negative regulation of granulocyte differentiation
GO:0035019	somatic stem cell maintenance
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732	positive regulation of protein catabolic process
GO:0051246	regulation of protein metabolic process
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
GO:2000001	regulation of DNA damage checkpoint
GO:2000819	regulation of nucleotide-excision repair