Version 5.4
Mus musculus Gene: Cul4a
Summary
InnateDB Gene IDBG-134595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cul4a
Gene Name cullin 4A
Synonyms 2810470J21Rik; AW495282
Species Mus musculus
Ensembl Gene ENSMUSG00000031446
Encoded Proteins
IDBP-134597
cullin 4A
IDBP-401655
cullin 4A
IDBP-537280
cullin 4A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139842:
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:13105621-13147940
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000016680 ENSMUSP00000016680
ENSMUST00000121426 ENSMUSP00000112525
ENSMUST00000135371
ENSMUST00000141315
ENSMUST00000125514 ENSMUSP00000123074
ENSMUST00000139316
ENSMUST00000142700
ENSMUST00000125646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 230 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 230 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008284 positive regulation of cell proliferation
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0030097 hemopoiesis
GO:0030853 negative regulation of granulocyte differentiation
GO:0035019 somatic stem cell maintenance
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0051246 regulation of protein metabolic process
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000001 regulation of DNA damage checkpoint
GO:2000819 regulation of nucleotide-excision repair
Cellular Component
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139842
View Gene Order
ENSBTAG00000020093
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu03420
Nucleotide excision repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa03420
Nucleotide excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PXT5
UniProt Splice Variant
Entrez Gene 99375
UniGene
RefSeq NM_146207 XM_006508933 XM_006508934 XM_006508935
OMIM
CCDS CCDS52485
HPRD
IMGT
MGI ID MGI:1914487
MGI Symbol Cul4a
EMBL AC133520
GenPept
RNA Seq Atlas 99375

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca