Version 5.4
Mus musculus Protein: Akr1b3
Summary
InnateDB Protein IDBP-134600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akr1b3
Protein Name aldo-keto reductase family 1, member B3 (aldose reductase)
Synonyms Ahr-1; Ahr1; Akr1b1; Aldor1; Aldr1; ALR2; AR;
Species Mus musculus
Ensembl Protein ENSMUSP00000100045
InnateDB Gene IDBG-134598 (Akr1b3)
Protein Structure
UniProt Annotation
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Abundant in the testis, skeletal muscle and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0043795 glyceraldehyde oxidoreductase activity
Biological Process
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1353494
InterPro IPR020471 Aldo/keto reductase subgroup
IPR023210 NADP-dependent oxidoreductase domain
PFAM PF00248
PRINTS PR00069
PIRSF PIRSF000097
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P45376
PhosphoSite PhosphoSite-P45376
TrEMBL Q3UDY1
UniProt Splice Variant
Entrez Gene 11677
UniGene Mm.485946
RefSeq NP_033788
MGI ID
MGI Symbol Akr1b3
OMIM
CCDS CCDS19990
HPRD
IMGT
EMBL AB016665 AK139250 AK149861 AK150197 AK153949 AK164682 AK170663 BC004725 BC021655 CH466533 D32250 L39795 U29152 U89140 U89142 U89143 U89144 U89145 U89146 U89147 U89148 U89149 U89150 U93230 U93231
GenPept AAA62176 AAA69958 AAC13358 AAD32300 AAH04725 AAH21655 BAA06980 BAA76413 BAE23933 BAE29130 BAE29373 BAE32272 BAE37874 BAE41944 EDL13695

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca