Version 5.4
| Mus musculus Gene: Akr1b3 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-134598.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Akr1b3 | ||||||||||||||||||||||
| Gene Name | aldo-keto reductase family 1, member B3 (aldose reductase) | ||||||||||||||||||||||
| Synonyms | Ahr-1; Ahr1; Akr1b1; Aldor1; Aldr1; ALR2; AR | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000001642 | ||||||||||||||||||||||
| Encoded Proteins |
aldo-keto reductase family 1, member B3 (aldose reductase)
aldo-keto reductase family 1, member B3 (aldose reductase)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085662:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 6:34303934-34317497 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | B1 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Pregnenolone biosynthesis pathway
Metabolism of steroid hormones and vitamin D pathway
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| KEGG |
Fructose and mannose metabolism pathway
Pentose and glucuronate interconversions pathway
Galactose metabolism pathway
Glycerolipid metabolism pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Pregnenolone biosynthesis pathway
Metabolism of lipids and lipoproteins pathway
Metabolism of steroid hormones and vitamin D pathway
Metabolism pathway
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| KEGG |
Galactose metabolism pathway
Pentose and glucuronate interconversions pathway
Fructose and mannose metabolism pathway
Glycerolipid metabolism pathway
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| INOH |
Fructose Mannose metabolism pathway
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| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | P45376 | ||||||||||||||||||||||
| TrEMBL | D3YVJ7 Q3TCL2 Q3UDY1 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 11677 | ||||||||||||||||||||||
| UniGene | Mm.389126 Mm.390393 Mm.427949 Mm.451 Mm.485946 | ||||||||||||||||||||||
| RefSeq | NM_009658 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS19990 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:1353494 | ||||||||||||||||||||||
| MGI Symbol | Akr1b3 | ||||||||||||||||||||||
| EMBL | AB016665 AC164578 AK139250 AK149861 AK150197 AK153949 AK164682 AK170663 BC004725 BC021655 CH466533 D32250 L39795 U29152 U89140 U89142 U89143 U89144 U89145 U89146 U89147 U89148 U89149 U89150 U93230 U93231 | ||||||||||||||||||||||
| GenPept | AAA62176 AAA69958 AAC13358 AAD32300 AAH04725 AAH21655 BAA06980 BAA76413 BAE23933 BAE29130 BAE29373 BAE32272 BAE37874 BAE41944 EDL13695 | ||||||||||||||||||||||
| RNA Seq Atlas | 11677 | ||||||||||||||||||||||